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Registrants of domain names also sometimes wish to register the domain names themselves (e.g., "XYZ.COM") as trademarks for perceived advantages, such as an extra bulwark against their domain being hijacked, and to avail themselves of such remedies as confusion or passing off against other domain holders with confusingly similar or intentionally misspelled domain names.

As with other trademarks, the domain name will not be subject to trademark registration unless the proposed mark is actually used to identify the registrant's goods or services to the public, rather than simply being the location on the Internet where the applicant's web site appears. Amazon.com is a prime example of a protected trademark for a domain name central to the public's identification of the company and its products.

Terms which are not protectable by themselves, such as a generic term or a merely descriptive term that has not acquired secondary meaning, may become registerable when a Top-Level Domain Name (e.g. dot-COM) is appended to it. An example of such a domain name ineligible for trademark or service mark protection as a generic term, but which currently has a registered U.S. service mark, is "HEARSAY.COM". Striped SilkSatin Shirt Loewe Affordable Cheap Price Clearance Visit Official Cheap Price Discount Big Sale b8g88Z

Among trademark practitioners there remains a great deal of debate around trademark protection under ICANN 's proposed generic top-level domain name space expansion. World Trademark Review has been reporting on the at times fiery discussion between trademark owners and domainers. [42]

Although there are systems which facilitate the filing, registration or enforcement of trademark rights in more than one jurisdiction on a regional or global basis, it is currently not possible to file and obtain a single trademark registration which will automatically apply around the world. Like any national law, trademark laws apply only in their applicable country or jurisdiction, a quality which is sometimes known as "territoriality".

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Main article: Madrid system

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Sarah K. Brode , Michael A. Campitelli , Jeffrey C. Kwong , Hong Lu , Alex Marchand-Austin , Andrea S. Gershon , Frances B. Jamieson , Theodore K. Marras
European Respiratory Journal 2017 50: 1700037; DOI: 10.1183/13993003.00037-2017
Sarah K. Brode
Division of Respirology, Dept of Medicine, University of Toronto, Toronto, ON, Canada Dept of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada Division of Respiratory Medicine, West Park Healthcare Centre, Toronto, ON, Canada
Michael A. Campitelli
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Jeffrey C. Kwong
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada Public Health Ontario, Toronto, ON, Canada Dept of Family and Community Medicine, University of Toronto, Toronto, ON, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Hong Lu
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Alex Marchand-Austin
Public Health Ontario, Toronto, ON, Canada
Andrea S. Gershon
Division of Respirology, Dept of Medicine, University of Toronto, Toronto, ON, Canada Institute for Clinical Evaluative Sciences, Toronto, ON, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada Dept of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Frances B. Jamieson
Public Health Ontario, Toronto, ON, Canada Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Theodore K. Marras
Division of Respirology, Dept of Medicine, University of Toronto, Toronto, ON, Canada Dept of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada

Abstract

Inhaled corticosteroid (ICS) use is associated with an increased risk of pneumonia. This study was performed to determine if ICS use is associated with an increased risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) or tuberculosis (TB).

We conducted a population-based nested case–control study using linked laboratory and health administrative databases in Ontario, Canada, including adults aged ≥66 years with treated obstructive lung disease ( asthma, chronic obstructive pulmonary disease (COPD) or asthma–COPD overlap syndrome) between 2001 and 2013. We estimated odds ratios comparing ICS use with nonuse among NTM-PD and TB cases and controls using conditional logistic regression.

Among 417 494 older adults with treated obstructive lung disease, we identified 2966 cases of NTM-PD and 327 cases of TB. Current ICS use was associated with NTM-PD compared with nonuse (adjusted OR (aOR) 1.86, 95% CI 1.60–2.15) and was statistically significant for fluticasone (aOR 2.09, 95% CI 1.80–2.43), but not for budesonide (aOR 1.19, 95% CI 0.97–1.45). There was a strong dose–response relationship between incident NTM-PD and cumulative ICS dose over 1 year. There was no significant association between current ICS use and TB (aOR 1.43, 95% CI 0.95–2.16).

This study suggests that ICS use is associated with an increased risk of NTM-PD, but not TB.

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